15 Conditions Research Says CBD Could Target

CBD is touted for benefiting a lot of conditions thanks to research like this

CBD has quickly grown into a massive industry with some pretty impressive claims to make. But what does the actual peer-reviewed evidence have to say about CBD?

Well, here’s a short breakdown of 15 different conditions peer-reviewed research suggests CBD targets. While there is a lot more evidence out there for those interested in reading it, this guide will give you a quick overview of things.


A report out of Vanderbilt University concluded CBD is a viable treatment option for stress-related neuropathic disorders, including chronic anxiety. The researchers found evidence transient anxiety was reversed after the introduction of CBD.


Researchers at the University of Naples conducted a report looking into the impact of CBD on inflammation. The researchers found cannabidiol significantly reduces the expression of inflammation in human biopsies. They believe CBD should be viewed as a viable treatment option for a wide range of inflammation-based conditions.


Research out of the University College London found that CBD significantly reduced the number of cigarettes smoked when compared with placebo groups. The team showed that CBD spray, taken as needed, decreasing participants’ intake of cigarettes by approximately 40%.


A report conducted by The University of California, San Francisco, indicated several important ways in which CBD could benefit gastrointestinal health. They identified regulation of motility, reduction of inflammation, and pain relief as key contributors. Impressively, half of the participants were so successful with CBD, and they were able to stop taking another daily medication.


Evidence published by the National University of Ireland strongly indicates a viable connection between the endocannabinoid system and stress relieving responses. The report notes a process by which CBD helps mitigate certain types of brain activity to reduce the impact of chronic stress.


A 2013 study conducted by researchers at the University of Nebraska was looking into how cannabinoids impact metabolic processes, and vice versa. To do this, they tested the fasting insulin and glucose levels of participants and compared the CBD group with the control. They concluded CBD use is associated with lower fasting insulin levels, as well as smaller waist size.


A review of all the available evidence out of the Rockefeller University concluded CBD has a distinct ability to help treat depression and anxiety. The clinical and preclinical data show CBD receptors offer a viable solution for treating psychological disorders, such as depression. They found evidence endocannabinoid system dysfunction is associated with higher rates of depression.

Skin Conditions

An interesting report by researchers at the University of Debrecen found evidence of endocannabinoid receptors in “virtually all tissues.” They also showed the receptors located in the various layers of skin play a vital role in controlling a balance between the creation of new cells, differentiation, and survival. The evidence supporting this connection is robust, although understanding how it functions will take more research.


A report out of the Hospital Research Institute in Barcelona, Spain found compelling evidence of a connection between CBD and a reduction in several fibromyalgia symptoms. The team confirmed that just two hours after administration, CBD was able to significantly reduce pain and stiffness, while also raising relaxation and sleep quality index scores.

Heart Disease

A 2010 report out of Robert Gordon University showed evidence CBD could target specific forms of heart disease. In their test, providing lab rats with CBD ten minutes before a coronary artery occlusion resulted in a sharp reduction in the number of arrhythmias and infarct size. Interestingly, this reduction was shown to be dose-dependent.


Research out of Dokkyo University in Japan found evidence that CBD may play a more significant role in respiratory health than previously thought. In their testing of guinea pig models, the CB2 receptor, activated by CBD, was shown to prevent the activation of C fibers. That helps inhibit respiratory inflammation associated with asthma.

Sleep Disorders

A study conducted by researchers at the University of Illinois at Chicago uncovered evidence that CBD medication can help stabilize breathing patterns during sleep, improving overall quality. The team believes this is thanks to a change in the upper airway muscles, but more research is needed.


A team of researchers from the University of Glasgow published a randomized trial of CBD-based prescription Sativex. They found strong evidence medication can significantly reduce chronic pain, as well as spasticity associated with multiple sclerosis.


Research out of Northwestern University Medical School wanted to understand how the endocannabinoid system can impact the treatment of central nervous system disorders, such as Parkinson’s. The team showed that not only does CBD fight oxidative damage from these disorders, but it can also help mitigate chronic pain as well.


Research out of the University of Manchester tested the effectiveness of CBD to improve the significant symptoms of migraine, such as nausea, photophobia, and pain. Their data shows that CBD was effective at treating all three symptoms thanks to an interaction primarily with the CNR1 receptor.


Did CBD Work?

All of this research on CBD helps improve our understanding of how to maximize its effectiveness, but it also makes things pretty daunting for newcomers. Luckily, one site is attempting to fill the gap between peer-reviewed research and user-generated reviews.

DidCBDWork.com has dedicated pages for various conditions associated with CBD, where you’ll find all of these reports and many more. They’re currently asking a million people how CBD worked for them, and they’d love to hear from you. Together we can all build a more well informed and healthy world!

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